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Full Of It #192 - TGN1412 (Patreon)

Published:
2022-02-22 19:59:47
Imported:
2022-06

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In London in March of 2006, six men fell foul of a catastrophic biopharmaceutical trial when a drug called TGN1412, developed to treat a kind of leukemia, caused them to go into multiple organ failure and develop an appearance that led to them being referred to as "The Elephant Men". 

The disastrous trial would go on to drastically change how drug testing would be carried out in the future, internationally.


The Drug Trial: Emergency at the Hospital - https://www.youtube.com/watch?v=a9_sX93RHOk

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Anonymous

Hello doll! Listening as I fall asleep which is a regular occurrence for me. I like to listen to these pods as I head to bed because who can resist your dulcet tones! I usually catch the first 20 mins or so on a good night before I start to drift off and then I’ll continue on with the rest of it the next night. You’ve gotten me through long train journeys, flights, boring days at work, walks on the beach, sleepless nights and I’ve been known to listen to you to drown out the snores of men who insist on staying over after a hookup. But alas, thank you for being apart of my everyday life :)

Anonymous

jaboody dubs - dump cakes is a parody video on a tv infomercial!! it's also where 'you ever take a dump in a mug?' comes from https://youtu.be/S8rNRmmosmA

Anonymous

I've never participated in a drug trial myself but I did have a co-worker I worked with for a few years who did them regularly. We work together in the restaurant industry so sometimes money is better than other times. When she needed money she would do a drug trial. This is how she explained it to me how it works, you have to go in and get like a physical and get everything checked out before you do anything at all then you have to sign the paperwork saying that you know they're not liable. It is pretty difficult to qualify she said. And then there are different trials tiers, the first one being like you come in and they give you a medication to try and you have to sit there for three or four hours and then you go home and then the next one up would be you have to stay there all day and then you can go home and then the next one up would be like overnight studies where you had to stay at the hospital for like extended period of observation. The ones that my friend did were like in the first tier where they would give you different medications and you had to hang out for a few hours and then you were able to go home. She said she would make between like $150 to like 5 or $600 doing them. The lower the tier you do the less money you get. It worked out really well for her because it's a few hours and a few hundred dollars. She even got her boyfriend into it and he was doing the same. As far as I know they never had any bad reactions or any trouble at all. She really didn't tell people or talk about the fact that she did these studies because people always looked down on her like only people that are scummy do stuff like that. Which is really sad. Also depending on where you live the rules for studies vary, just depends on your state's law and counties law where I'm from(Seattle Washington, USA) and all that jazz. Thank you for the great podcast!

Anonymous

Cannot even begin to imagine the lasting effect this traumatic experience must have had on their mental health, how absolutely horrendous. I too have no recollection of this and was likely too busy being an insufferable teenager at the time.

Anonymous

would you consider doing a pod about the Thalidomide scandal, it was givin to pregnant women during the the late 1950s and early 1960s, it resulted in the "biggest man‐made medical disaster ever," resulting in more than 10,000 children born with a range of severe deformities, such as phocomelia, as well as thousands of miscarriages. I like the Idea of having char, and nova on for your 200th episode.

Anonymous

That opening song, Olympia... straight to hell you go.

Anonymous
>>78459111

Also, re Britpop, it was always Blur v Oasis, but all the cool kids knew that Pulp were the better group.

Anonymous
>>78459111

Being born under a milky moon just makes me think of that giant tit from Benidorm Festival

Anonymous

My father was part of a drug trial pretty recently for a drug to treat penile curvature (we are weirdly open and this is casual discussion in my family). One of the possible side effects was anaphylaxis. This man, a lifelong allergy sufferer who should recognize an allergic reaction, has the audacity to tell me and my mom about driving home from his injection one day that he suddenly had tingling going up his throat and making it hard to breathe. It took both of us 20 minutes to convince him this was an allergic reaction and maybe he needs to mention it to the administrators. I guess this is a good example that as much as people are aware that they need to report things for a trial like this, people that do not have any prior medical training might not know/recognize what is important to communicate to the administrators. However, it sounds like in this situation, even if the people experiencing the drug had spoken up more, the administrators would have continued anyway, which is horrendous. I think it would be great to have Char on for the 200th episode and have her deep dive into a spooky true crime story with you. She was amazing in the Grim Tour video, you can tell how much she loves that kind of shet.

Anonymous

A lot of people, me included, seem to think dury duty would be cool and interesting and intense like something off of a crime show, but anyone Ive ever spoken to whose done it has said it was boring, drawn out and tiring, even people who have been on semi interesting trials

Murray

I can't believe for once I am the patron that has a weird link to the podcast subject. I'm a pharmacist in a hospital and work in the cancer treatment centre where we make up the chemotherapy (including clinical trial drugs). Funnily enough i'd never heard of this incident before, but i've heard of many like it. As someone else suggested above, you should really look into the Thalidomide crisis. It is often considered the most disastrous case of a drug testing fuck up in the history of the UK/world and changed so much about how we now test and regulate new medicines. It was introduced as a new treatment for morning sickness in pregnant women and it worked well and caused no harm to the mother. At the time however, scientists did not believe any drug could cross the placenta to the baby and believed that it was safe to give to pregnant women. No testing on teratogenic effects were done on thalidomide, and as a result it ended up causing birth defects in more than 10,000 children. It seems ridiculous now that they did not test the effects on the fetus, but as you said hindsight is a funny thing. The sad reality is there have been thousands of incidents in healthcare where things have had to go terribly wrong before we realise the flaws in our practice. I could talk for hours about other fucked up incidents but I think i'll leave it there for now. Great Podcast x

Murray
>>78569228

Another interesting point I just remembered. After the thalidomide incident, thalidomide was pulled from the market but was later re-introduced in the treatment of cancer and leprosy where it is still used to this day. :)

Anonymous

Have you heard of the origins of viagra? It was originally designed and tested as a heart medication, but during its clinical trials all the men reported side effects of prolonged erections. So it was rather quickly rebranded and made Pfizer a pretty penny! Much nicer than the cytokine (you pronounced it correctly FYI) storm. A pod with Char would be such a good idea

Anonymous

Great pod! I don't know when you record but I usually see new episodes around 7 PM in my area so I hope I made the cut-off date. never participated in a clinical trial of anything but when I was a teenager I dabbled in cosplay, and a hair product company (I think Bed Head?) company offered people a sample of a hair paste/temporary blue hair color to try as a soft launch. The product was incredibly thick and sticky and I had to wash it out with cooking oil but thankfully didn't leave any permanent damage. And relating to British medical malpractice, I recently discovered much of the childhood vaccine hesitancy in the 00s was primarily stoked by disgraced British doctor Andrew Wakefield, who sought to profit from his own vaccine by convincing the public the existing ones caused autism, and had to preform tests he knew he wasn't going to get results from to seem more credible.

Anonymous

Oh my word! How scary! Medical ethics is such a touchy subject, the amount you learn about it in school is ridiculous seeing as nearly nobody uses it in daily life. I’m surprised the men got out of it relatively unscathed but it just goes to show even the professionals get it wrong some times (stupid professionals at least). Looks like they were able to remove the cause, but not the symptom. Also the elephant man doesn’t look a fucking thing like and elephant. Thanks for the fabulous pod darling!